Roguelike deckbuilder Slay the Spire is very highly regarded for, among other things, deep strategic planning and complex interactions between cards and other game mechanics (you should check it out).

Reddit plays this one turn per day, hosted by https://www.reddit.com/user/greenlaser73/ . The current season just started with (the character) the Watcher.

Will the current run result in a heart kill at the end of act 4?

Resolves YES on heart kill ONLY. Resolves NO in any other outcome, including no act 4, failure, abandonment by the host, AI apocalypse, etc. Resolves at run conclusion or if the host abandons, disappears unexpectedly for at least 2 months, or is turned into paperclips.