Will the UCSF AER002 phase 2 pilot trial show statistically significantly positive results? | Manifold

Will the UCSF AER002 phase 2 pilot trial show statistically significantly positive results?

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Trial registration: https://classic.clinicaltrials.gov/ct2/show/NCT05877508

This will resolve based on the primary outcome measure only:

Change in Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Score from Baseline.

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There are multiple different outcome measures. A very likely result is that some show improvement while others don’t. How does the question account for this?

Good point. This will resolve based on the primary outcome measure only:

Change in Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Score from Baseline.

bought Ṁ5 NO

So a statistically significant increase compared to placebo group in the Primary outcome measure. Hmmmm, I’m betting No.

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Will the Phase 2 Trials of Lepodisiran be a Success?

Will the pre-clinical results on the cancer drug AOH1996 be broadly confirmed by independent team(s)?

Will the M72/AS01E tuberculosis vaccine candidate have an efficacy of 50% or higher in the phase 3 trial?

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