tl;dr Follistatin therapy is investigated for multiple therapeutic uses, including treating muscle disorders, countering muscle loss in aging, and potentially aiding in muscle regeneration and strength enhancement.

Follistatin is a protein encoded by the FST gene, with the highest concentration found in the female ovary and the skin. It is involved in the development of the embryo and has inhibitory action on bone morphogenic proteins (BMPs), which are involved in the formation of various tissues in the body.

Follistatin is also being studied for its role in the regulation of muscle growth, as it binds activin and attenuates the release of follicle-stimulating hormone (FSH). It is an autocrine glycoprotein that binds and neutralizes members of the TGF-β superfamily.

Some studies have shown that follistatin may have benefits for muscle growth, inflammation, and fertility, and it has gained attention in bodybuilding circles. However, the actual benefits of follistatin on muscle growth may not be as significant as believed.

Learn more: https://pubmed.ncbi.nlm.nih.gov/35537048/