Will there be a genetic engineering method capable of changing an adult's chromosomal sex by 2100?
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Most cells' karyotypes (excluding neuronal cells) would have to be changeable from XX to XY or vice versa after any required amount of time, as long as it lies within the human lifespan of that time.

If only one way is achieved, the market resolves 50%.

If it is achieved only for a non-human mammal, the market resolves 20% (resp. 10%).

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Would it be safe? Probably if done correctly it should be safe. At least no more dangerous than being XXY or being on hormone replacement therapy. Though those don’t come without their side effects, people can be healthy with them.

Exists in a bleeding-edge experiment done once, or actually available for people to use?

God, I wish. Betting NO as insurance.

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