A serious problem is any of the following:
Any permanent loss of stored email contents.
Any service disruption that lasts for at least 12 hours and results in outbound emails being lost with no bounce notification, or inbound emails being lost in any way.
Any service disruption that lasts for at least 72 hours and results in users being unable to read emails in their normal client, or unable to send emails.
A security breach caused by illicit access (not a Swiss court order), which results in private user data being shared without their permission.
The Swiss government becomes able to legally read email contents.
In all cases the issue must affect at least 1% of all users (or all active users). It also must be ProtonMail's fault, not e.g. those users all happening to have spyware.
I may modify this list to improve it, but not in response to something that just happened.