https://twitter.com/StoopMensch/status/1734240901676015623
The biggest blackpill on current longevity research is that there aren’t any 30 year old lab mice
You’re telling me you want humans to live forever and you can’t even get a mouse to midlife crisis yet??
THIS IS THE DECADE IN WHICH WE GET DRUGS DIRECTLY FOR LONGEVITY INTO THE CLINIC
Sept 2023
@LeoSpitz Sounds a bit bullshitty to me. We already have drugs that happen to consistently provide small lifespan extensions for basically everybody (e.g. statins). So yeah, we might get some more, nice, but not a fundamental change. I also don't see how you run a trial demonstrating longevity benefits that are not directly from treating a condition in <10 years. You literally have to wait for people to die of old age so unless your target population is already very old and ill this is going to take a loooong time.
@MartinModrak Yes, it is impossible to test a cure for aging in 7 years. I don’t understand how this market is still so out of touch with reality.
@capybara It’s not impossible. You can easily see age reversal very quickly via epigenetic reprogramming.
@Odamaron Age reversal isn’t the same as a cure for aging. If the “cure” results in cancer development, then it’s not a cure. Another example: if the “cure” only works for 10 years, then it’s not a cure for aging. But you can’t know unless you wait and see.
@jeremiahsamroo So if I stop someone’s pain by killing them, that counts as a cure for their pain? If someone’s aging is cured temporarily and then kills them, that is a cure for aging?
@capybara You can decouple the rejuvenating aspect of reprogramming from cell identity changes, which would prevent cancer development. The science has advanced.
@Odamaron you cannot be sure that side effects don’t have long term pernicious effects on aging without an extended trial. I agree that in theory, a treatment for aging could be promising by 2030, but we couldn’t be confident by 2030.
@DanielKilian would you mind updating the description with clear and complete resolution criteria? Thanks!
The AOH1996 drug FDA approval question has similar odds, highlighting how I think this question is too high at 25%. Surely curing cancer is a sub-goal of curing aging? Will cancer drugs be pointless after 2030?
https://manifold.markets/Tossup/will-aoh1996-be-fda-approved-before?r=Y2FweWJhcmE
@capybara Aging is the most potent carcinogen. The risk of cancer increases 4000% from age 25 to 65.
@capybara Why would that matter? The question is only about curing aging. If it does that but has some other side effect, it still did it.
@LightLawliet Side effect of death? I can cure your aging but you die tomorrow…that counts as yes?
@slawbunnies If there was any cure to aging, billionaires would not die. Since they die all the time, there is no cure.
@slawbunnies Very interesting, hadn't heard of this before! Has there been any further work from the initial 2010 paper?
https://manifold.markets/ArunJohnson/will-300-lifespan-extension-in-roti?r=QXJ1bkpvaG5zb24