Will FDA approve any mRNA vaccine against pancreatic adenocarcinoma before 2028?
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Resolves YES if the FDA grants full approval for the commercial sale of any mRNA vaccine against pancreatic adenocarcinoma in the United States before January 1, 2028. This does not include emergency use authorization or other forms of limited authorization. Resolves NO otherwise.
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AFAIK the only real candidate here is the KRAS vaccine (mRNA-5671). I think it might work against some of the cancers but pancreatic is pretty unlikely - pancreatic quite low mutational load, and is not normally responsive to immunotherapy. If it works I would expect it to be restricted to MSI-high pancreatic.
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