This question concerns flagship universities in the United States, as defined in this Wikipedia category (as of 10/23/2024)
Several potential factors could drive such a closure within the next decade:
Political conflict, especially in regions like the South
Disruptions from AI or alternative education models
Financial collapse or bankruptcy
Broader collapse or major restructuring of the higher education system
1,000
3.00https://www.brookings.edu/articles/are-colleges-really-facing-an-enrollment-cliff/
"Even some of the nation’s most successful universities have undergone recent program closures. The Pennsylvania State University reduced employment by 10% at its regional campuses this spring as enrollment fell about 20%, even while enrollment at the flagship Penn State campus grew. Last year, West Virginia University, the state’s flagship school, announced cuts of 28 programs and elimination of 147 faculty positions. WVU’s enrollment has been more or less flat for the last five years, but is down about 16% over the last decade. The University of Wisconsin-Milwaukee is closing its College of General Studies and removing 32 tenured faculty, having also seen about a 16% enrollment drop over the last decade. Most recently, St. Louis University has announced the need for large budget cuts in the face of a massive drop in international enrollment, which disproportionately contributes to tuition revenues."