Generally legal means restrictions on its use are typical for medical care (e.g. you have to go to a doctor for a prescription, but doctors are available) and it is possible to get testosterone, estradiol, and at least one kind of effective antiandrogen legally. Florida, Alabama, Utah, and South Dakota currently currently are the only states to not meet these criteria.

If it is unclear whether restrictions qualify and a particular edge case would affect the result of the market, I'll conduct a poll for how it should resolve among my friends who have not bet on this market.