F-22s have performed combat sorties and have bombed targets in Syria and elsewhere. They have also shot down an alleged Chinese spy balloon and some other high-altitude objects. There is, as far as I can tell, not a confirmed kill of a manned military aircraft from this type.

The question will resolve to Yes if a F-22 shoots down a manned figher, bomber, transport or other military aircraft from the time of posting this question and before January 1st, 2030. Helicopters count as valid kills fo. Accidental kills also count, just as long as they don't involve aircraft collision. The target must be in the air, not on the ground or carrier deck.