The destination does not necessarily need to be the orbit of another star, but the mission should enter interstellar space. For the purposes of this market, "interstellar space" begins simply at 150 AU from the Sun.
How should this resolve if the human component of the mission is heavily mediated by exotic technologies? For example:
* A robotic mission travels to a distant location, carrying human gametes or zygotes, with the capability of gestating them in artificial uteruses, & robotically taking care of human children, until these adult humans assume some command roles in the mission?
* The human astronauts are cyborgs with biological brains connected to artificial systems.
* The human astronauts have no biological components, being computationally emulated on a neuron-by-neuron basis.