https://en.wikipedia.org/wiki/Church%E2%80%93Turing%E2%80%93Deutsch_principle
Resolves once there's a complete consensus among philosophers, physicists, and computer scientists, akin to the current consensus that free energy is impossible under known physics. Probably this won't happen until we have a Theory of Everything and the ability to perform experiments using exotic physics like black hole hypercomputation.
This market cares only about physics questions that could actually in principle occur. Not hypothetical questions like "what would happen if we had negative matter". (Unless it turns out there is some way to create negative matter.)
1,000I educated myself on this with only chatgpt and it seems to me impossible, we won't know enough about the universe by 2100, some things will remain hidden, thus imperfect accuracy.
It would still be yes if enough people got together and claimed success because they made the rules and set the bar low enough. So, NO, we won't know enough by that date to compute true to the actual universe simulations with perfect fidelity, but 🤷?