Arbitrage opportunity: https://manifold.markets/Ernie/will-the-fda-approve-a-diseasemodif-66892f6005c3

@strutheo How do you define "cure"? And how do you define Parkinson's disease? It's more like a syndrome and there are ongoing efforts to redefine it (see Neuronal alpha-Synuclein Disease). Monogenic PD (GBA or LRKK2) seems different from sporadic PD and therefore treatment might also differ.

One option could be "An FDA approved disease-modifying treatment for sporadic Parkinson's disease".

@adssx yes more like that fda definition

@strutheo Thanks. Metaculus is at 2031 btw: https://www.metaculus.com/questions/12790/disease-modifying-treatment-for-parkinsons/

https://twitter.com/EricTopol/status/1779898447224844527

This month, two phase 2 trial results published: Roche's alpha-synuclein targeting prasinezumab showed motor benefits in some subgroups, and repurposing of lixisenatide might slow down the progression of motor symptoms.

@adssx hopeful! ty for sharing

@strutheo Update on the above phase 2 results... Some bad news:

Prasinezumab phase 2b failed (but very close to statistical significance so they'll might still go to phase 3 at least in some subgroups...): https://ir.prothena.com/investors/press-releases/news-details/2024/Roches-Phase-IIb-Study-of-Prasinezumab-Missed-Primary-Endpoint-But-Suggests-Possible-Clinical-Benefit-in-Early-Stage-Parkinsons-Disease/default.aspx

Exenatide phase 3 (same family as lixisenatide) failed.

Roche’s Phase IIb study of prasinezumab missed primary endpoint, but suggests possible benefit in early-stage Parkinson’s disease

PADOVA study showed numerical delay in motor progression and positive trends on multiple secondary and exploratory endpointsPrasinezumab continues to be well tolerated and no new safety signals were...

@adssx rip

Nah, it is complex question, as there are already approved treatments for Parkinson's. This article summarizes which treatments are approved by FDA. Genetix shall solve nothing for this disease. So far the treatments (either drugs or specific surgery implants) aim to reduce the motoric symptoms, while none of them can claim to reverse the process behind this disease. Also, consider that there are multiple mechanisms at play, and probably the entity itself (Parkinsons disease) shall be changed to reflect all of the new findings and possibilities for halting those mechanisms...

@d_c_ https://www.apdaparkinson.org/what-is-parkinsons/treatment-medication/medication/

@d_c_ thanks for the link, i was aware there were treatments, this was more for an FDA approved cure, as unlikely as it might seem.

https://theconversation.com/newly-discovered-genetic-variant-that-causes-parkinsons-disease-clarifies-why-the-condition-develops-and-how-to-halt-it-226435

no takers?