Some context: EY has tried for years to lose weight with various levels of success. There's this legendary EY meme from a few years back:

"I will delete comments suggesting diet or exercise"
Seems like he's still searching for ideas: https://twitter.com/ESYudkowsky/status/1724196658253357199
I'm inclined to believe that he has a particularly difficult time losing weight due to genetics, but still find it hard to believe that strict diet and exercise wouldn't get him to his weight goals.
Examples of "diet and exercise" could be, but is not limited to:
Working out for 1 hour, 4-5 days a week, at an intensity that is reasonable for his level and the duration of the exercise.
Calorie restriction diet containing high protein, high fiber, low carb, no refined sugar.
For example a day could consist of:
Breakfast: Greek yoghurt with almonds/walnuts and some berries.
Dinner: Turkey/chicken with vegetables.
Snack: 1 banana/apple
He has to be committed to this for at least 6 months, with very small amounts of cheating allowed.
"reasonable amount of weight" means an amount where we could intuitively conclude that "diet and exercise" worked for EY. If there's substantial controversy there will be a community poll.
Resolves N/A in 2027 if he hasn't done it by then (except if he's in the process of doing it, then we'll wait until he's done or quits)
I will not bet in this market.