The Targeting Aging with Metformin (TAME) trial is a long-discussed randomized, double-blind, placebo-controlled trial of metformin's ability to ameliorate diseases of aging spearheaded by Nir Barzilai. Despite lots of media coverage and indications that it's proceeding soon, it still isn't listed on clinicaltrials.gov, and there's no clear indication when or if it will happen.

This question resolves YES only if the Targeting Aging with Metformin (TAME) trial appears on clinicaltrials.gov by 11:59 PM on December 31, 2023 with one of the following statuses:

• Recruiting

• Enrolling by invitation

• Active, not recruiting

You can check this easily here:

https://www.clinicaltrials.gov/search?term=targeting%20aging%20with%20metformin%20(TAME)&aggFilters=status:rec%20act%20enr&checkSpell=false