Resolves to my credence in 2030.
"The infectious hypothesis proposes that a pathogen (virus, bacteria, prion, etc.) is the root cause of AD [2]. The hypothesis is supported by evidence that some pathogens, such as herpesviruses and certain bacterial species, are found more commonly in AD patients." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660461/#:~:text=The%20infectious%20hypothesis%20proposes%20that,more%20commonly%20in%20AD%20patients.
Close date updated to 2030-01-01 4:59 am
Feb 9, 8:05am: Is a pathogen (virus, bacteria, prion, etc.) the root cause of Alzheimer's disease? → Is a pathogen (virus, bacteria, prion, etc.) a root cause of Alzheimer's disease?
Feb 9, 8:11am: Is a pathogen (virus, bacteria, prion, etc.) a root cause of Alzheimer's disease? → Does any pathogen (virus, bacteria, prion, etc.) cause Alzheimer's disease?
Abysmal statistics; incomplete literature
But probably true (shingles vax has been shown to inhibit beta h-viruses more generally; and female brains already show very different responses to dementia risk factors)
Not sure why it takes four people to write a mediocre paper (epidemiology has the talent depth of the average car wash ) but conclusions look sound
@LachlanMunro Relevant link from that Tweet: https://www.medrxiv.org/content/10.1101/2023.05.23.23290253v1
Basically they compared people born a week before versus a week after a cutoff date for eligibility for that vaccine, and found a 20%-ish reduction in dementia diagnosis in the latter group. (Still pending peer review.)
@egroj Thanks for the question. Thinking about it further, I think it will be difficult to say which is the “root cause”, so I changed the question to just a cause. If anyone needs a refund, let me know.