I'm looking to donate some of my mana balance this year, at least $10k worth of mana (drawn from my mana salary). Where will I send it?

In the past, I've mostly gone with defaults like:

• Givewell's recommended top charities

• EA Funds's donor lottery

This year I've become much more familiar with the EA community, and expect to have different preferences based on knowing the people at some of these orgs and following their work more closely. Roughly speaking, I'm sympathetic to longtermism and GHD more than animal welfare/biosecurity, and most excited about things that look startupy/cruxy/manifoldy.

But I'd love to hear about excellent opportunities I may have missed, via free response entries or comments!

I'll aim to donate at least $10k to one single charity, and will resolve this market to the first such charity I do so for 2022.