My Mom was cured of Leukemia by taking Nexavar. 1000's of other cancer patients are taking it and being cured, Off Label. For some it delays mortality for years, when their prognosis survival rate is less than a year. This gives them time to find another cure. Or for Chemo to begin working which can take a year, without this drug. But it is expensive! As a society we cannot afford this price for millions of patients, if it were not subsidized by the manufacturer Bayer. There is a generic available now since Bayer made the original in 2005. If more research were done, and it were used for other types of Cancer, millions would be saved! They could have years more of quality life. Why are we not prescribing this Off Label? I am not a Doctor, I only have a Mom who was saved.
Nexavar or generic prescribed to over 1 million cancer patients worldwide by December 31, 2025? Yes or No?
Nexavar (sorafenib) is approved for treating advanced renal cell carcinoma, unresectable hepatocellular carcinoma, and differentiated thyroid carcinoma refractory to radioactive iodine treatment. This market predicts whether the cumulative number of patients prescribed Nexavar On and Off label will exceed 1 million. Resolution will be based on official sales and prescription data released by Bayer HealthCare Pharmaceuticals Inc. or reputable industry reports. If this data is not available I will estimate the number of patients taking this drug.
The current number of On Label prescriptions, and Off Label use:
https://chatgpt.com/share/682c7fdc-308c-8011-858c-33a368a82767
1,000It's important to understand that this drug works only for people who have cancers that are driven by a specific version of an enzyme. People who have different kinds of cancer won't be helped and could even be hurt by this drug. For most patients, immunotherapy or other more potent TKIs are now recommended.
So while it's great it was effective for your mom, it's not a general-purpose wonder drug. The good news is that we now have even better medicine than that.
@WilliamGunn Should it work for AML with FLT-3 mutation? Does this cancer have the specific version of the enzyme you mentioned?
@SteveBright You don't need to go into details if you don't want, but I'd be curious how long ago was she treated, if this was a new diagnosis, and if there were any other treatments alongside?
Soratinib does inhibit FLT3, so that could be why it was effective for your mom if that's the only treatment she received, but as great as it is she responded, you should know response to a drug like this (a TKI) usually doesn't last more than a few years. Given that this was an unusual treatment, I would ask how long you have and why standard treatments weren't an option.