Science gives a "breakthrough of the year" every year

Examples of what they named the year's most significant event in the last 4 years:
2020: COVID-19 vaccine, developed and tested at record speed[38]

2021: An AI brings protein structures to all[39]

2022: James Webb Space Telescope debut[40]

2023: GLP-1 Drugs[41]

Link for the 2023 article: https://en.wikipedia.org/wiki/Breakthrough_of_the_Year?useskin=vector

This should be an exciting market to track people's best guesses about the most important science of 2024 in real-time.

Please look at the suggested answers so far and only propose answers that haven't been suggested yet. Mods will not resolve to answers on topic that have already been suggested will not be resolved to.

They will not multi resolve.

If there is a lot of ambiguity after the announcement comes out, resolvers will hear arguments about what to resolve in the comments. If nobody suggests an answer close enough to the breakthrough most significant event, they will resolve other but I think that is unlikely.