Is Cannabinoid Hyperemesis Syndrome Caused by an Overstimulation of the CB1 Receptors?
5
56
200
2026
62%
chance

https://www.ncbi.nlm.nih.gov/books/NBK549915/

Cannabinoid hyperemesis syndrome is becoming more prevalent in emergency rooms, yet awareness and early detection remain low. While the leading theory suggests an overstimulation of the CB1 receptors, there is insufficient evidence to support this hypothesis.

Resolves Yes if it's proven overstimulation of the CB1 receptors is a contributing factor to developing CHS.

Resolves No if it's proven that there is no link between CHS and overstimulation of the CB1 receptors.

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Interesting market. I placed a small bet in the “more likely than not” direction given the importance of the CB1 receptor to cannabis consumption and tolerance, but it’s really a shot in the dark. I’m wondering how could could prove/disprove this hypothesis, and what that study would look like. I’m also only seeing a handful of clinical trials registered studying CHS, so it may be awhile before this can be resolved.

@benmanns Yeah I wouldn't be surprised if we still weren't sure what's going on with CHS in 2030. The medical industry as a whole isn't taking this very serious. It's the emergency rooms seeing most of these cases and it's hard to get a clear diagnosis. CDC doesn't even have information on it yet.

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