Will we be able to generate all stable protein conformations from a sequence by 2027? | Manifold

Will we be able to generate all stable protein conformations from a sequence by 2027?

Basic

8

Ṁ124

Dec 31

24%

chance

1D

1W

1M

ALL

Right now, Alphafold2 generates only the 3D structure for one of many possible protein conformations, with no way of easily guessing the alternative stable confirmations or the free energy associated to them.

As important as structure prediction is, do you think it will be upgraded for the prediction of free energy landscapes before the beginning of 2027?

There must be a scientific consensus, as there is with the effectiveness of alphafold2. Possibly through comparison with the results of molecular dynamics simulations and/or experiments.

This question is managed and resolved by Manifold.

Get

1,000

and

3.00

Sort by:

I think it is quite possible, perhaps even likely to predict free energy landscapes. Which is very much not the same as "generate all possible protein conformations", an impossible task!

@Zozo001CoN I have changed the question from "possible" to "stable", which may be less ambiguous. Would not predicting the free energy landscape imply that it is possible to know all stable conformations?

@EnriqueAlanis well no - the landscape is a collection of relatively low energy conformations (and pathways among them), that excludes theoretically stable local minima which are unreachable from the ground state

Related questions

Will the protein folding problem be essentially solved before 2040?

Will a drug designed with significant contribution from an AlphaFold-like system pass a Phase I trial by end of 2025?

Will quantum mechanical properties prove explanatory for another biological process by the end of 2024?

Will it be possible to sequence a full human genome for US$50 by 2026?

Will it be possible to obtain FDA approval for a drug based on protein folding stimulations without human clinical trials by 2035?

Which of these protein targets will have at least one new drug targeting them receive FDA approval between 2025 and 2030

Will any foundation models/LLMs be able to reliably come up with novel unparalleled misalignments before EOY 2024?

Will automated chemical synthesis produce heavy nitrogen/hydrogen versions of every amino acid >50% of sites by EOY 2025

Will we be able to edit our own genomes by 2050?

Will whole genome synthesis be developed for eukaryotic organisms before 2040?

Related questions

Will the protein folding problem be essentially solved before 2040?

Which of these protein targets will have at least one new drug targeting them receive FDA approval between 2025 and 2030

Will a drug designed with significant contribution from an AlphaFold-like system pass a Phase I trial by end of 2025?

Will any foundation models/LLMs be able to reliably come up with novel unparalleled misalignments before EOY 2024?

Will quantum mechanical properties prove explanatory for another biological process by the end of 2024?

Will automated chemical synthesis produce heavy nitrogen/hydrogen versions of every amino acid >50% of sites by EOY 2025

Will it be possible to sequence a full human genome for US$50 by 2026?

Will we be able to edit our own genomes by 2050?

Will it be possible to obtain FDA approval for a drug based on protein folding stimulations without human clinical trials by 2035?

Will whole genome synthesis be developed for eukaryotic organisms before 2040?

© Manifold Markets, Inc.•Terms + Mana-only Terms•Privacy•Rules