Personalized medicine based on patient's genetic profile

 Artificial Wombs for Human Gestation (from conception to birth)

Universal Flu Vaccine (effictive against all current and future strains)

Self-Healing Materials for Infrastructure

Cancer Vaccine Targeting Multiple Types of Cancer

City-scale fully automated underground logistics networks

Therapies to reverse neurodegenerative diseases

Therapies to reverse cardiovascular diseases

Synthetic Meat Indistinguishable from Real Meat

Smart Contact Lenses with AR Capabilities

Biohybrid Robots with Living Muscle Tissue

Room-Temperature Atmospheric-Pressure Superconductors

Room-Temperature Superconducting Transmission Lines in Urban Power Grids

Commercial satellite to ground power transmission

Human Missions to Mars with Round-Trip Travel Time Under 6 Months

A Specific ‘Longevity Drug’ or Defined Drug Combination that Extends Average Human Healthspan by at Least 10 Years 

Self-Replicating Fully-Automated Factories

Space probes travelling at >=1% speed of light

Cell replacement therapy using synthetic cells

Self-Actuating Metamaterials for Adaptive Structures in Buildings and Infrastructure

Autonomous Drone Swarms Dominating Land and Air Combat

Temporal Cloaking Device (Hiding Events in Time)

Reality Anchoring Device (Stabilizing Subjective Reality)

Engineered Symbiotic Microorganism Implants for Human Physiological Augmentation

Artificial Photosynthesis (10% efficiency in converting sunlight to chemical energy)

Quantum Sensors Enabling Detection of Cancer Years Before Symptoms

Food with bioengineered saturated fat that doesn't raise cholesterol

Desalination with Energy Consumption Below 1.5 kWh/m³

Humanoid Robots in Service/Logistics Roles

Solid-state EV batteries ≥ 500 Wh/kg in mass-produced cars 

Transoceanic fully autonomous container crossing without onboard crew

Point-to-Point Suborbital Spaceflight (Regularly Scheduled Passenger Transport)

Resolves YES for any number of technologies that are widespread enough in 2049 but not in 2024. 

If it is unclear whether any given technology meets these requirements before 2050, resolves to some subjective percentage value.