* Any machine learning system must be involved in finding the solution directly, or finding new algorithms (in which case, new mathematics also resolves yes).

** New algorithm, lowering the computational complexity compared to currently known algorithms:

- Number field sieve, if the computations  were performed on a classical computer.

- Shor's algorithm, if the computations were performed on a quantum computer.

All options may resolve No, for example if this is achieved by just scaling up computational power. The question stays open until the number is factored.