Is Cannabinoid Hyperemesis Syndrome Caused by an Overstimulation of the CB1 Receptors?

Question

https://www.ncbi.nlm.nih.gov/books/NBK549915/

Cannabinoid hyperemesis syndrome is becoming more prevalent in emergency rooms, yet awareness and early detection remain low. While the leading theory suggests an overstimulation of the CB1 receptors, there is insufficient evidence to support this hypothesis.

Resolves Yes if it's proven overstimulation of the CB1 receptors is a contributing factor to developing CHS.

Resolves No if it's proven that there is no link between CHS and overstimulation of the CB1 receptors.

Manifold Markets · Answer

Roughly even odds — Manifold Markets prediction market estimates a 57% chance (8 traders, as of Mar 26, 2026).