As there is not a defined "worldwide pestilence" benchmark to my knowlesge, the resolution criteria will be somewhat subjective and in the spirit of the question (I will not bet in this market).

Some things that could lead this to resolve YES (not an exclusive list):

-Outbreaks in a large number of countries and cities around the world that generates substantial news coverage

-Substantial countermeasures from a number of nations to eradicate bedbugs or prevent bedbugs from entering their borders

-Epidemic(s) of bedbug spread diseases in several nations

I will confer with subject matter experts if the resolution is unclear.

https://x.com/_evfm/status/1710283896925909365?s=46&t=62uT9IruD1-YP-SHFkVEPg